Liquid Chromatography–Mass Spectrometry (LC-MS)

LC-MS (Liquid Chromatography–Mass Spectrometry) is a highly advanced analytical technique that combines the separation power of liquid chromatography with the precise identification capabilities of mass spectrometry. Unlike standard chemical testing methods, LC-MS offers unmatched sensitivity, accuracy, and specificity making it the preferred tool for in-depth analysis in pharmaceutical development, clinical diagnostics, environmental testing, and scientific research.

LC-MS works by first separating the sample into its individual components using liquid chromatography. Then, each compound is introduced into the mass spectrometer, where it is ionized and analyzed based on its mass-to-charge ratio. This dual process not only separates complex mixtures but also accurately identifies and quantifies compounds, even at trace levels in highly complex matrices.

LC-MS can detect and measure an extensive range of substances, including:

• Trace-level impurities and degradation products

• Drugs and drug metabolites in biological samples

• Peptides, proteins, and biomarkers

• Pesticides and environmental pollutants

• Vitamins and active compounds in supplements

• Hormones and endocrine disruptors

• Natural products and plant-based compounds

• Food additives, contaminants, and preservatives